17O NMR Spectroscopy: A Novel Probe for Characterizing Protein Structure and Folding.

ABSTRACT: Oxygen is a key atom that maintains biomolecular structures, regulates various physiological processes, and mediates various biomolecular interactions. Oxygen-17 (17O), therefore, has been proposed as a useful probe that can provide detailed information about various physicochemical features of proteins. This is attributed to the facts that (1) 17O is an active isotope for nuclear magnetic resonance (NMR) spectroscopic approaches; (2) NMR spectroscopy is one of the most suitable tools for characterizing the structural and dynamical features of biomolecules under native-like conditions; and (3) oxygen atoms are frequently involved in essential hydrogen bonds for the structural and functional integrity of proteins or related biomolecules. Although 17O NMR spectroscopic investigations of biom

SUBMITTER: Muniyappan S 

PROVIDER: S-EPMC8223985 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature