An Integrative Bioinformatic Analysis for Keratinase Detection in Marine-Derived Streptomyces.

ABSTRACT: Keratinases present promising biotechnological applications, due to their ability to degrade keratin. Streptomyces appears as one of the main sources of these enzymes, but complete genome sequences of keratinolytic bacteria are still limited. This article reports the complete genomes of three marine-derived streptomycetes that show different levels of feather keratin degradation, with high (strain G11C), low (strain CHD11), and no (strain Vc74B-19) keratinolytic activity. A multi-step bioinformatics approach is described to explore genes encoding putative keratinases in these genomes. Despite their differential keratinolytic activity, multiplatform annotation reveals similar quantities of ORFs encoding putative proteases in strains G11C, CHD11, and Vc74B-19. Comparative genomics cla

SUBMITTER: Valencia R 

PROVIDER: S-EPMC8224001 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature