Cell transplantation to replace retinal ganglion cells faces challenges - the Switchboard Dilemma.

ABSTRACT: The mammalian retina displays incomplete intrinsic regenerative capacities; therefore, retina degeneration is a major cause of irreversible blindness such as glaucoma, age-related macular degeneration and diabetic retinopathy. These diseases lead to the loss of retinal cells and serious vision loss in the late stage. Stem cell transplantation is a great promising novel treatment for these incurable retinal degenerative diseases and represents an exciting area of regenerative neurotherapy. Several suitable stem cell sources for transplantation including human embryonic stem cells, induced pluripotent stem cells and adult stem cells have been identified as promising target populations. However, the retina is an elegant neuronal complex composed of various types of cells with different functi

SUBMITTER: Liu Y 

PROVIDER: S-EPMC8224141 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature