MiR-548d-3p Alters Parasite Growth and Inflammation in <i>Leishmania (Viannia) braziliensis</i> Infection.

ABSTRACT: American Tegumentary Leishmaniasis (ATL) is an endemic disease in Latin America, mainly caused in Brazil by Leishmania (Viannia) braziliensis. Clinical manifestations vary from mild, localized cutaneous leishmaniasis (CL) to aggressive mucosal disease. The host immune response strongly determines the outcome of infection and pattern of disease. However, the pathogenesis of ATL is not well understood, and host microRNAs (miRNAs) may have a role in this context. In the present study, miRNAs were quantified using qPCR arrays in human monocytic THP-1 cells infected in vitro with L. (V.) braziliensis promastigotes and in plasma from patients with ATL, focusing on inflammatory response-specific miRNAs. Patients with active or self-healed cutaneous leishmaniasis patients, wit

SUBMITTER: Souza MA 

PROVIDER: S-EPMC8224172 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature