Biodistribution of extracellular vesicles following administration into animals: A systematic review.

ABSTRACT: In recent years, attention has turned to examining the biodistribution of EVs in recipient animals to bridge between knowledge of EV function in vitro and in vivo. We undertook a systematic review of the literature to summarize the biodistribution of EVs following administration into animals. There were time-dependent changes in the biodistribution of small-EVs which were most abundant in the liver. Detection peaked in the liver and kidney in the first hour after administration, while distribution to the lungs and spleen peaked between 2-12 h. Large-EVs were most abundant in the lungs with localization peaking in the first hour following administration and decreased between 2-12 h. In contrast, large-EV localization to the liver increased as the levels in the lungs decreased. There was mod

SUBMITTER: Kang M 

PROVIDER: S-EPMC8224174 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature