Integrated analyses of m¹A regulator-mediated modification patterns in tumor microenvironment-infiltrating immune cells in colon cancer.

ABSTRACT: Emerging evidence has revealed the crucial role of transcriptional RNA methyladenosine modification in immune response. However, the potential role of RNA N1-methyladenosine (m¹A) modification of immune cells in the tumor microenvironment (TME) still remains unclear. In this study, we identified three distinct m¹A modification patterns based on the integrated analyses of nine m¹A regulators, which are significantly related to Relapse-free survival (RFS), Overall survival (OS), and TME infiltration cells in colon cancer patients. Furthermore, the m1AScore was generated by using principal components analysis (PCA) of expression of the 71 m¹A-related genes to further demonstrate the characteristics of m¹A patterns in colon cancer. In summ

SUBMITTER: Gao Y 

PROVIDER: S-EPMC8224220 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature