Targeting SUMOylation in Plasmodium as a Potential Target for Malaria Therapy.

ABSTRACT: Malaria is a parasitic disease that represents a public health problem worldwide. Protozoans of the Plasmodium genus are responsible for causing malaria in humans. Plasmodium species have a complex life cycle that requires post-translational modifications (PTMs) to control cellular activities temporally and spatially and regulate the levels of critical proteins and cellular mechanisms for maintaining an efficient infection and immune evasion. SUMOylation is a PTM formed by the covalent linkage of a small ubiquitin-like modifier protein to the lysine residues on the protein substrate. This PTM is reversible and is triggered by the sequential action of three enzymes: E1-activating, E2-conjugating, and E3 ligase. On the other end, ubiquitin-like-protein-specific proteases in yea

SUBMITTER: Sumam de Oliveira D 

PROVIDER: S-EPMC8224225 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature