Synergistic Activation of Antitumor Immunity by a Particulate Therapeutic Vaccine.

ABSTRACT: Success in anticancer immune therapy relies on stimulation of tumor antigen-specific T lymphocytes and effective infiltration of the T cells into tumor tissue. Here, a therapeutic vaccine that promotes proliferation and tumor infiltration of antigen-specific T cells in both inflamed and noninflamed tumor types is described. The vaccine consists of STING agonist 2'3'-cGAMP, TLR9 ligand CpG, and tumor antigen peptides that are loaded into nanoporous microparticles (μGCVax). μGCVax is effective in inhibiting lung metastatic melanoma, primary breast cancer, and subcutaneous colorectal cancer in their respective murine models, including functional cure of HER2-positive breast cancer. Mechanistically, μGCVax potently stimulates type I interferon expression in dendritic cells

SUBMITTER: Mai J 

PROVIDER: S-EPMC8224417 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature