A Microstirring Pill Enhances Bioavailability of Orally Administered Drugs.

ABSTRACT: Majority of drugs are administered orally, yet their efficient absorption is often difficult to achieve, with a low dose fraction reaching the blood compartment. Here, a microstirring pill technology is reported with built-in mixing capability for oral drug delivery that greatly enhances bioavailability of its therapeutic payload. Embedding microscopic stirrers into a pill matrix enables faster disintegration and dissolution, leading to improved release profiles of three widely used model drugs, aspirin, levodopa, and acetaminophen, without compromising their loading. Unlike recently developed drug-carrying nanomotors, drug molecules are not associated with the microstirrers, and hence there is no limitation on the loading capacity. These embedded microstirrers are fabricated through the a

SUBMITTER: Mundaca-Uribe R 

PROVIDER: S-EPMC8224427 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature