Steroids Enable Mesenchymal Stromal Cells to Promote CD8⁺ T Cell Proliferation Via VEGF-C.

ABSTRACT: Mesenchymal stromal cells (MSCs) function as a formidable regulator of inflammation and tissue homeostasis and expanded MSCs are shown to be effective in treating various inflammatory diseases. Their therapeutic effects require the existence of certain inflammatory cytokines. However, in the absence of sufficient proinflammatory stimuli or in the presence of anti-inflammatory medications, MSCs are animated to promote immune responses and unable to alleviate inflammatory disorders. In this study, it is demonstrated that steroid co-administration interferes the efficacy of MSCs in treating acute graft-versus-host disease (aGvHD). Molecular analysis reveals that vascular endothelial growth factor C (VEGF-C) is highly induced in MSCs by steroids and TNFα and VEGF-C in turn promotes CD8<

SUBMITTER: Gan Y 

PROVIDER: S-EPMC8224440 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature