A synthetic opioid vaccine attenuates fentanyl-vs-food choice in male and female rhesus monkeys.

ABSTRACT:

Aim

Opioid-targeted vaccines are under consideration as candidate Opioid Use Disorder medications. We recently reported that a fentanyl-targeted vaccine produced a robust and long-lasting attenuation of fentanyl-vs-food choice in rats. In the current study, we evaluated an optimized fentanyl-targeted vaccine in rhesus monkeys to determine whether vaccine effectiveness to attenuate fentanyl choice translated to a species with greater phylogenetic similarity to humans.

Methods

Adult male (2) and female (3) rhesus monkeys were trained to respond under a concurrent schedule of food (1 g pellets) and intravenous fentanyl (0, 0.032-1 μg/kg/injection) reinforcement during daily 2 h sessions. Fentanyl choice dose-effect functions were determined daily and 7-day buprenorphine treatme

SUBMITTER: Townsend EA 

PROVIDER: S-EPMC8224470 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature