Censoring Trace-Level Environmental Data: Statistical Analysis Considerations to Limit Bias.

ABSTRACT: Trace-level environmental data typically include values near or below detection and quantitation thresholds where health effects may result from low-concentration exposures to one chemical over time or to multiple chemicals. In a cook stove case study, bias in dibenzo[a,h]anthracene concentration means and standard deviations (SDs) was assessed following censoring at thresholds for selected analysis approaches: substituting threshold/2, maximum likelihood estimation, robust regression on order statistics, Kaplan-Meier, and omitting censored observations. Means and SDs for gas chromatography-mass spectrometry-determined concentrations were calculated after censoring at detection and calibration thresholds, 17% and 55% of the data, respectively. Threshold/2 substitution was the least biased.

SUBMITTER: George BJ 

PROVIDER: S-EPMC8224532 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature