Fluoroarene Separations in Metal-Organic Frameworks with Two Proximal Mg²⁺ Coordination Sites.

ABSTRACT: Fluoroarenes are widely used in medicinal, agricultural, and materials chemistry, and yet their production remains a critical challenge in organic synthesis. Indeed, the nearly identical physical properties of these vital building blocks hinders their purification by traditional methods, such as flash chromatography or distillation. As a result, the Balz-Schiemann reaction is currently employed to prepare fluoroarenes instead of more atom-economical C-H fluorination reactions, which produce inseparable mixtures of regioisomers. Herein, we propose an alternative solution to this problem: the purification of mixtures of fluoroarenes using metal-organic frameworks (MOFs). Specifically, we demonstrate that controlling the interaction of fluoroarenes with adjacent coordinatively unsaturated Mg<

SUBMITTER: Zick ME 

PROVIDER: S-EPMC8224537 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature