Autophagy Induction as a Host-Directed Therapeutic Strategy against Mycobacterium tuberculosis Infection.

ABSTRACT: Tuberculosis (TB), a bacterialinfectious disease caused by Mycobacterium tuberculosis (M.tb), which causes significant mortality in humans worldwide. Current treatment regimen involve the administration of multiple antibiotics over the course of several months that contributes to patient non-compliance leading to relapse and the development of drug-resistant M.tb (MDR and XDR) strains. Together, these facts highlight the need for the development of shorter TB treatment regimens. Host-directed therapy (HDT) is a new and emerging concept that aims to augment host immune response using drugs/compounds with or without adjunct antibiotics against M.tb infection. Autophagy is a natural catabolic mechanism of the cell that involves delivering the cytosolic constituents

SUBMITTER: Adikesavalu H 

PROVIDER: S-EPMC8224563 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature