Attacking COVID-19 Progression Using Multi-Drug Therapy for Synergetic Target Engagement.

ABSTRACT: COVID-19 is a devastating respiratory and inflammatory illness caused by a new coronavirus that is rapidly spreading throughout the human population. Over the past 12 months, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the virus responsible for COVID-19, has already infected over 160 million (>20% located in United States) and killed more than 3.3 million people around the world (>20% deaths in USA). As we face one of the most challenging times in our recent history, there is an urgent need to identify drug candidates that can attack SARS-CoV-2 on multiple fronts. We have therefore initiated a computational dynamics drug pipeline using molecular modeling, structure simulation, docking and machine learning models to predict the inhibitory activity of several million compou

SUBMITTER: Coban MA 

PROVIDER: S-EPMC8224684 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature