Whole-exome sequencing reveals insights into genetic susceptibility to Congenital Zika Syndrome.

ABSTRACT: Congenital Zika Syndrome (CZS) is a critical illness with a wide range of severity caused by Zika virus (ZIKV) infection during pregnancy. Life-threatening neurodevelopmental dysfunctions are among the most common phenotypes observed in affected newborns. Risk factors that contribute to susceptibility and response to ZIKV infection may be related to the virus itself, the environment, and maternal genetic background. Nevertheless, the newborn's genetic contribution to the critical illness is still not elucidated. Here, we aimed to identify possible genetic variants as well as relevant biological pathways that might be associated with CZS phenotypes. For this purpose, we performed a whole-exome sequencing in 40 children born to women with confirmed exposure to ZIKV during pregnancy. We inves

SUBMITTER: Borda V 

PROVIDER: S-EPMC8224898 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature