Evaluation of leukopenia during sepsis as a marker of sepsis-defining organ dysfunction.

ABSTRACT:

Background

Although both leukocytosis and leukopenia have been considered Systemic Inflammatory Response Syndrome criteria, leukopenia is not generally considered a normal response to infection. We sought to evaluate the prognostic validity of leukopenia as a sign of sepsis-defining hematological organ dysfunction within the Sepsis-3 framework. We hypothesized that leukopenia is associated with higher risk of mortality than leukocytosis among patients with suspected infection.

Methods

We performed a retrospective cohort study using the Medical Information Mart v1.4 in Intensive Care-III database. Multivariable regression models were used to evaluate the association between leukopenia and mortality in patients with suspected infection defined by Sepsis-3.

Results

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SUBMITTER: Belok SH 

PROVIDER: S-EPMC8224900 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature