The Goto Kakizaki rat: Impact of age upon changes in cardiac and renal structure, function.

ABSTRACT:

Background

Patients with diabetes are at a high risk for developing cardiac dysfunction in the absence of coronary artery disease or hypertension, a condition known as diabetic cardiomyopathy. Contributing to heart failure is the presence of diabetic kidney disease. The Goto-Kakizaki (GK) rat is a non-obese, non-hypertensive model of type 2 diabetes that, like humans, shares a susceptibility locus on chromosome 10. Herein, we perform a detailed analysis of cardio-renal remodeling and response to renin angiotensin system blockade in GK rats to ascertain the validity of this model for further insights into disease pathogenesis.

Methods

Study 1: Male GK rats along with age matched Wistar control animals underwent longitudinal assessment of cardiac and renal function for 32 week

SUBMITTER: Meagher P 

PROVIDER: S-EPMC8224913 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature