Anesthetic protocols for urodynamic studies of the lower urinary tract in small rodents-A systematic review.

ABSTRACT: Urodynamic studies in rats and mice are broadly used to examine pathomechnisms of disease and identify and test therapeutic targets. This review aims to highlight the effects of the anesthetics on the lower urinary tract function and seeks to identify protocols that allow recovery from anesthesia and repeated measurements while preserving the function which is being studied. All studies published in English language, which compared the data obtained under various types of anesthesia and the urodynamics performed in awake animals were included. It appears that urethane, an anesthetic recommended extensively for the investigation of lower urinary tract function, is appropriate for acute urodynamic studies only. Major advantages of urethane are its stability and ability to preserve the mictur

SUBMITTER: Abdelkhalek AS 

PROVIDER: S-EPMC8224928 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature