Identification of Putative Markers That Predict the In Vitro Senescence of Mesenchymal Progenitor Cells.

ABSTRACT: Mesenchymal progenitor cells (MPCs) are a promising cell source for regenerative medicine because of their immunomodulatory properties, anti-inflammatory molecule secretion, and replacement of damaged cells. Despite these advantages, heterogeneity in functional potential and limited proliferation capacity of MPCs, as well as the lack of suitable markers for product potency, hamper the development of large-scale manufacturing processes of MPCs. Therefore, there is a sustained need to develop highly proliferative and standardized MPCs in vitro and find suitable functional markers for measuring product potency. In this study, three lines of pluripotent stem cell (PSC)-derived MPCs with high proliferative ability were established and compared with bone-marrow-derived MPCs using proliferation a

SUBMITTER: Shin EY 

PROVIDER: S-EPMC8225148 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature