ELAVL1 primarily couples mRNA stability with the 3' UTRs of interferon-stimulated genes.

ABSTRACT: Upon pathogen detection, the innate immune system triggers signaling events leading to upregulation of pro-inflammatory and anti-microbial mRNA transcripts. RNA-binding proteins (RBPs) interact with these critical mRNAs and regulate their fates at the post-transcriptional level. One such RBP is ELAVL1. Although significant progress has been made in understanding how embryonic lethal vision-like protein 1 (ELAVL1) regulates mRNAs, its target repertoire and binding distribution within an immunological context remain poorly understood. We overlap four high-throughput approaches to define its context-dependent targets and determine its regulatory impact during immune activation. ELAVL1 transitions from binding overwhelmingly intronic sites to 3' UTR sites upon immune stimulation of cells, bind

SUBMITTER: Rothamel K 

PROVIDER: S-EPMC8225249 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature