Mast Cell Activation in the Systemic Sclerosis Esophagus.

ABSTRACT:

Introduction

Previously, we discovered similar esophageal gene expression patterns in patients with systemic sclerosis (SSc) and eosinophilic esophagitis (EoE) where eosinophil/mast cell-targeted therapies are beneficial. Because SSc and EoE patients experience similar esophageal symptoms, we hypothesized that eosinophil/mast cell-directed therapy may potentially benefit SSc patients. Herein, we determine the association between esophageal mast cell quantities, gene expression and clinical parameters in order to identify SSc patients who may benefit from eosinophil/mast cell-directed therapy.

Methods

Esophageal biopsies from SSc patients and healthy participants were stained for tryptase, a mast cell marker, and associations with relevant clinical parameters including 24h es

SUBMITTER: Tom K 

PROVIDER: S-EPMC8225255 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature