Omics in a Digital World: The Role of Bioinformatics in Providing New Insights Into Human Aging.

ABSTRACT:

Background

Aging is a complex phenotype influenced by a combination of genetic and environmental factors. Although many studies addressed its cellular and physiological age-related changes, the molecular causes of aging remain undetermined. Considering the biological complexity and heterogeneity of the aging process, it is now clear that full understanding of mechanisms underlying aging can only be achieved through the integration of different data types and sources, and with new computational methods capable to achieve such integration.

Recent advances

In this review, we show that an omics vision of the age-dependent changes occurring as the individual ages can provide researchers with new opportunities to understand the mechanisms of aging. Combining results from single-ce

SUBMITTER: Dato S 

PROVIDER: S-EPMC8225294 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature