Steroid hormone pathways coordinate developmental diapause and olfactory remodeling in Pristionchus pacificus.

ABSTRACT: Developmental and behavioral plasticity allow animals to prioritize alternative genetic programs during fluctuating environments. Behavioral remodeling may be acute in animals that interact with host organisms, since reproductive adults and the developmentally arrested larvae often have different ethological needs for chemical stimuli. To understand the genes that coordinate the development and host-seeking behavior, we used the entomophilic nematode Pristionchus pacificus to characterize dauer-constitutive mutants (Daf-c) that inappropriately enter developmental diapause to become dauer larvae. We found two Daf-c loci with dauer-constitutive and cuticle exsheathment phenotypes that can be rescued by the feeding of Δ7-dafachronic acid, and that are dependent on the conserved canonical ster

SUBMITTER: Carstensen HR 

PROVIDER: S-EPMC8225345 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature