HIV-1 Transmission linkages among persons with incident infection to inform public health surveillance.

ABSTRACT:

Background

We evaluated features of HIV transmission networks involving persons diagnosed during incident HIV infection (IHI) to assess network-based opportunities to curtail onward transmission.

Methods

Transmission networks were constructed using partial pol sequences reported to North Carolina surveillance among persons with recent (2014-2018) and past (<2014) HIV diagnoses. IHI were defined as documented acute infections or seroconversion. Demographic and virologic features of HIV genetic clusters (<1.5% pairwise genetic distance) involving ≥ 1 IHI were assessed. Persons with viral genetic links and who had diagnoses >90 days prior to an IHI were further characterized. We assessed named partner outcomes among IHI index persons using contact tracing data.

Findin

SUBMITTER: Dennis AM 

PROVIDER: S-EPMC8225702 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature