Frailty Worsens Antidepressant Treatment Outcomes in Late Life Depression.

ABSTRACT:

Objective

To investigate the relationship between frailty and treatment response to antidepressant medications in adults with late life depression (LLD).

Methods

Data were evaluated from 100 individuals over age 60 years (34 men, 66 women) with a depressive diagnosis, who were assessed for frailty at baseline (characteristics include gait speed, grip strength, activity levels, fatigue, and weight loss) and enrolled in an 8-week trial of antidepressant medication followed by 10 months of open-treatment.

Results

Frail individuals (n = 49 with ≥3 deficits in frailty characteristics) did not differ at baseline from the non/intermediate frail (n = 51 with 0-2 deficits) on demographic, medical comorbidity, cognitive, or depression variables. On average, frail individuals ex

SUBMITTER: Brown PJ 

PROVIDER: S-EPMC8225710 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature