Ontology highlight
ABSTRACT:
SUBMITTER: Rogers KA
PROVIDER: S-EPMC8225920 | biostudies-literature | 2021 Jun
REPOSITORIES: biostudies-literature
Rogers Kerry A KA Andritsos Leslie A LA Wei Lai L McLaughlin Eric M EM Ruppert Amy S AS Anghelina Mirela M Blachly James S JS Call Timothy T Chihara Dai D Dauki Anees A Guo Ling L Ivy S Percy SP James Lacey R LR Jones Daniel D Kreitman Robert J RJ Lozanski Gerard G Lucas David M DM Ngankeu Apollinaire A Phelps Mitch M Ravandi Farhad F Schiffer Charles A CA Carson William E WE Jones Jeffrey A JA Grever Michael R MR
Blood 20210601 25
Hairy cell leukemia (HCL) is a rare B-cell malignancy, and there is a need for novel treatments for patients who do not benefit from purine analogs. Ibrutinib, an oral agent targeting Bruton tyrosine kinase in the B-cell receptor signaling pathway, is highly effective in several malignancies. Its activity in HCL was unknown, so we conducted a multisite phase 2 study of oral ibrutinib in patients with either relapsed classic or variant hairy cell leukemia. The primary outcome measure was the over ...[more]