The Role of the Loading Condition in Predictions of Bone Adaptation in a Mouse Tibial Loading Model.

ABSTRACT: The in vivo mouse tibial loading model is used to evaluate the effectiveness of mechanical loading treatment against skeletal diseases. Although studies have correlated bone adaptation with the induced mechanical stimulus, predictions of bone remodeling remained poor, and the interaction between external and physiological loading in engendering bone changes have not been determined. The aim of this study was to determine the effect of passive mechanical loading on the strain distribution in the mouse tibia and its predictions of bone adaptation. Longitudinal micro-computed tomography (micro-CT) imaging was performed over 2 weeks of cyclic loading from weeks 18 to 22 of age, to quantify the shape change, remodeling, and changes in densitometric properties. Micro-CT based finite eleme

SUBMITTER: Cheong VS 

PROVIDER: S-EPMC8225949 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature