Comparative study of prophylaxis with high and low doses of voriconazole in children with malignancy.

ABSTRACT:

Background and purpose

Children with acute myeloid leukemia and relapses of leukemia are at high risk of developing fungal infections and need antifungal prophylaxis. This study aimed to compare the efficacy and toxicity of two different dosage regimens of voriconazole (VRC) during prophylactic administration in children with malignancy and neutropenia.

Materials and methods

This prospective study was conducted at the Belarusian Research Center for Pediatric Oncology, Hematology, and Immunology from May 2017 to December 2019. The present study included 21 Caucasian patients with malignant hematological diseases (20 patients with acute myeloid leukemia and relapses of leukemia and 1 patient with Non-Hodgkin's lymphoma) aged 2-18 years. All patients were randomly divided into

SUBMITTER: L Kandaurava S 

PROVIDER: S-EPMC8226053 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature