Long Distance From Microvessel to Cancer Cell Predicts Poor Prognosis in Non-Small Cell Lung Cancer Patients.

ABSTRACT:

Background

Blood supply, which is crucial for nutrition and drug delivery, was determined by microvessel density as well as the diffusion distance between vessels and cancer cells. Therefore, we evaluated the distance from microvessels to cancer cells (D_mvcc) and its role in the prognosis of non-small cell lung cancer (NSCLC) patients.

Methods

Patients with primary NSCLC were retrospectively analyzed. The tumor samples were immunochemically stained with CD31 to visualize the microvessels. The D_mvcc was defined as the mean distance from each microvessel to its nearest cancer cell in the "hot-spot" of an individual patient. The patients were stratified into short- and long-distance groups using five strategies, including dichotomy by the median value, opt

SUBMITTER: Ding H 

PROVIDER: S-EPMC8226084 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature