Association Between Minor Salivary Gland Biopsy During Sjоgren's Syndrome and Serologic Biomarkers: A Systematic Review and Meta-Analysis.

ABSTRACT:

Objective

Patients with primary Sjögren's syndrome (pSS) may develop a potentially severe disease with extra-glandular involvement and lymphoma insurgence. Minor salivary gland biopsy is routinely used in the disease diagnosis, but its potential role as a biomarker for clinical disease presentation and prognosis is still poorly understood.

Methods

We performed a systematic review and meta-analysis on clinical presentation and prognosis in pSS patients who underwent minor salivary gland biopsy at diagnosis according to the PRISMA guidelines.

Results

We included five retrospective studies and 589 pSS patients. Ectopic GCs presence was not associated with a significant increase in the odds ratio for the clinical variables explored such as salivary gland swelling, arthrit

SUBMITTER: Berardicurti O 

PROVIDER: S-EPMC8226119 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature