Identification of the Signature Associated With m⁶A RNA Methylation Regulators and m⁶A-Related Genes and Construction of the Risk Score for Prognostication in Early-Stage Lung Adenocarcinoma.

ABSTRACT:

Background

N6-methyladenosine (m⁶A) RNA modification is vital for cancers because methylation can alter gene expression and even affect some functional modification. Our study aimed to analyze m⁶A RNA methylation regulators and m⁶A-related genes to understand the prognosis of early lung adenocarcinoma.

Methods

The relevant datasets were utilized to analyze 21 m⁶A RNA methylation regulators and 5,486 m⁶A-related genes in m⁶Avar. Univariate Cox regression analysis, random survival forest analysis, Kaplan-Meier analysis, Chi-square analysis, and multivariate cox analysis were carried out on the datasets, and a risk prognostic model based on three feature genes was constructed.

Results

Respectively, we trea

SUBMITTER: Guo B 

PROVIDER: S-EPMC8226131 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature