STRIPAK, a Key Regulator of Fungal Development, Operates as a Multifunctional Signaling Hub.

ABSTRACT: The striatin-interacting phosphatases and kinases (STRIPAK) multi subunit complex is a highly conserved signaling complex that controls diverse developmental processes in higher and lower eukaryotes. In this perspective article, we summarize how STRIPAK controls diverse developmental processes in euascomycetes, such as fruiting body formation, cell fusion, sexual and vegetative development, pathogenicity, symbiosis, as well as secondary metabolism. Recent structural investigations revealed information about the assembly and stoichiometry of the complex enabling it to act as a signaling hub. Multiple organellar targeting of STRIPAK subunits suggests how this complex connects several signaling transduction pathways involved in diverse cellular developmental processes. Furthermore, recent pho

SUBMITTER: Kuck U 

PROVIDER: S-EPMC8226480 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature