Ontology highlight
ABSTRACT:
SUBMITTER: van der Linden RJ
PROVIDER: S-EPMC8226721 | biostudies-literature | 2021 Jun
REPOSITORIES: biostudies-literature
van der Linden Robert J RJ De Witte Ward W Poelmans Geert G
Genes 20210605 6
Late-onset Alzheimer's disease (AD) has a significant genetic and immunological component, but the molecular mechanisms through which genetic and immunity-related risk factors and their interplay contribute to AD pathogenesis are unclear. Therefore, we screened for genetic sharing between AD and the blood levels of a set of cytokines and growth factors to elucidate how the polygenic architecture of AD affects immune marker profiles. For this, we retrieved summary statistics from Finnish genome-w ...[more]