The Effectiveness of Glutathione Redox Status as a Possible Tumor Marker in Colorectal Cancer.

ABSTRACT: The role of oxidative stress (OS) in cancer is a matter of great interest due to the implication of reactive oxygen species (ROS) and their oxidation products in the initiation of tumorigenesis, its progression, and metastatic dissemination. Great efforts have been made to identify the mechanisms of ROS-induced carcinogenesis; however, the validation of OS byproducts as potential tumor markers (TMs) remains to be established. This interventional study included a total of 80 colorectal cancer (CRC) patients and 60 controls. By measuring reduced glutathione (GSH), its oxidized form (GSSG), and the glutathione redox state in terms of the GSSG/GSH ratio in the serum of CRC patients, we identified significant changes as compared to healthy subjects. These findings are compatible with the effect

SUBMITTER: Acevedo-Leon D 

PROVIDER: S-EPMC8226858 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature