The Antioxidant Activity of Limonene Counteracts Neurotoxicity Triggered byAβ_1-42 Oligomers in Primary Cortical Neurons.

ABSTRACT: Many natural-derived compounds, including the essential oils from plants, are investigated to find new potential protective agents in several neurodegenerative disorders such as Alzheimer's disease (AD). In the present study, we tested the neuroprotective effect of limonene, one of the main components of the genus Citrus, against the neurotoxicity elicited by Aβ_1-42 oligomers, currently considered a triggering factor in AD. To this aim, we assessed the acetylcholinesterase activity by Ellman's colorimetric method, the mitochondrial dehydrogenase activity by MTT assay, the nuclear morphology by Hoechst 33258, the generation of reactive oxygen species (ROS) by DCFH-DA fluorescent dye, and the electrophysiological activity of K_V3.4 potassium channel subunits by pa

SUBMITTER: Piccialli I 

PROVIDER: S-EPMC8227170 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature