P53/p73 Protein Network in Colorectal Cancer and Other Human Malignancies.

ABSTRACT: The p53 tumor suppressor protein is crucial for cell growth control and the maintenance of genomic stability. Later discovered, p63 and p73 share structural and functional similarity with p53. To understand the p53 pathways more profoundly, all family members should be considered. Each family member possesses two promoters and alternative translation initiation sites, and they undergo alternative splicing, generating multiple isoforms. The resulting isoforms have important roles in carcinogenesis, while their expression is dysregulated in several human tumors including colorectal carcinoma, which makes them potential targets in cancer treatment. Their activities arise, at least in part, from the ability to form tetramers that bind to specific DNA sequences and activate the transcription of

SUBMITTER: Horvat A 

PROVIDER: S-EPMC8227208 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature