Ontology highlight
ABSTRACT:
SUBMITTER: Pellerino A
PROVIDER: S-EPMC8227730 | biostudies-literature | 2021 Jun
REPOSITORIES: biostudies-literature
Pellerino Alessia A Brastianos Priscilla K PK Rudà Roberta R Soffietti Riccardo R
Cancers 20210609 12
Leptomeningeal metastases (LM) from solid tumors represent an unmet need of increasing importance due to an early use of MRI for diagnosis and improvement of outcome of some molecular subgroups following targeted agents and immunotherapy. In this review, we first discussed factors limiting the efficacy of targeted agents in LM, such as the molecular divergence between primary tumors and CNS lesions and CNS barriers at the level of the normal brain, brain tumors and CSF. Further, we reviewed path ...[more]