Differential Regulation of Cellular FAM111B by Human Adenovirus C Type 5 E1 Oncogenes.

ABSTRACT: The adenovirus type 5 (HAdV-C5) E1 transcription unit encodes regulatory proteins that are essential for viral replication and transformation. Among these, E1A and E1B-55K act as key multifunctional HAdV-C5 proteins involved in various steps of the viral replication cycle and in virus-induced cell transformation. In this context, HAdV-C5-mediated dysregulations of cellular factors such as the tumor suppressors p53 and pRB have been intensively investigated. However, cellular components of downstream events that could affect infection and viral transformation are widely unknown. We recently observed that cellular FAM111B is highly regulated in an E1A-dependent fashion. Intriguingly, previous reports suggest that FAM111B might play roles in tumorigenesis, but its exact functions are not know

SUBMITTER: Ip WH 

PROVIDER: S-EPMC8227810 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature