Loss of Selenov predisposes mice to extra fat accumulation and attenuated energy expenditure.

ABSTRACT: Selenoprotein V (SELENOV) is a new and the least conserved member of the selenoprotein family. Herein we generated Selenov knockout (KO) mice to determine its in vivo function. The KO led to 16-19% increases (P < 0.05) in body weight that were largely due to 54% higher (P < 0.05) fat mass accumulation, compared with the wild-type (WT) controls. The extra fat accumulation in the KO mice was mediated by up-regulations of genes and proteins involved in lipogenesis (Acc, Fas, Dgat, and Lpl; up by 40%-1.1-fold) and down-regulations of lipolysis (Atgl, Hsl, Ces1d, and Cpt1a; down by 36-89%) in the adipose tissues. The KO also decreased (P < 0.05) VO₂ consumption (14-21%), VCO₂ production (14-16%), and energy expenditure (14-23%), compared with the WT controls. SELENOV and O

SUBMITTER: Chen LL 

PROVIDER: S-EPMC8227834 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature