Dog10K_Boxer_Tasha_1.0: A Long-Read Assembly of the Dog Reference Genome.

ABSTRACT: The domestic dog has evolved to be an important biomedical model for studies regarding the genetic basis of disease, morphology and behavior. Genetic studies in the dog have relied on a draft reference genome of a purebred female boxer dog named "Tasha" initially published in 2005. Derived from a Sanger whole genome shotgun sequencing approach coupled with limited clone-based sequencing, the initial assembly and subsequent updates have served as the predominant resource for canine genetics for 15 years. While the initial assembly produced a good-quality draft, as with all assemblies produced at the time, it contained gaps, assembly errors and missing sequences, particularly in GC-rich regions, which are found at many promoters and in the first exons of protein-coding genes. Here, we presen

SUBMITTER: Jagannathan V 

PROVIDER: S-EPMC8228171 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature