Examination of the APOBEC3 Barrier to Cross Species Transmission of Primate Lentiviruses.

ABSTRACT: The transmission of viruses from animal hosts into humans have led to the emergence of several diseases. Usually these cross-species transmissions are blocked by host restriction factors, which are proteins that can block virus replication at a specific step. In the natural virus host, the restriction factor activity is usually suppressed by a viral antagonist protein, but this is not the case for restriction factors from an unnatural host. However, due to ongoing viral evolution, sometimes the viral antagonist can evolve to suppress restriction factors in a new host, enabling cross-species transmission. Here we examine the classical case of this paradigm by reviewing research on APOBEC3 restriction factors and how they can suppress human immunodeficiency virus (HIV) and simian immunodefic

SUBMITTER: Gaba A 

PROVIDER: S-EPMC8228377 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature