Approaches to Potentiated Neuroprotective Treatment in the Rodent Model of Ischemic Optic Neuropathy.

ABSTRACT: Nonarteritic anterior ischemic optic neuropathy (NAION) commonly causes sudden optic nerve (ON)-related vision loss. The rodent NAION model (rAION) closely resembles NAION in presentation and physiological responses. We identified early rAION-associated optic nerve head (ONH) inflammatory gene expression responses and the anti-inflammatory prostaglandin PGJ₂'s effects on those responses. We hypothesized that blocking pro-inflammatory prostaglandin (PGE₂) production by inhibiting monoacylglycerol lipase or cyclooxygenase activity and co-administering PGJ₂ would potentiate RGC survival following ischemic neuropathy. Deep sequencing was performed on vehicle- and PGJ₂-treated ONHs 3d post-rAION induction. Results were compared against responses from

SUBMITTER: Mehrabian Z 

PROVIDER: S-EPMC8228425 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature