A Novel Signature of CCNF-Associated E3 Ligases Collaborate and Counter Each Other in Breast Cancer.

ABSTRACT: Breast cancer (BRCA) malignancy causes major fatalities amongst women worldwide. SCF (Skp1-cullin-F-box proteins) E3 ubiquitin ligases are the most well-known members of the ubiquitination-proteasome system (UPS), which promotes cancer initiation and progression. Recently, we demonstrated that FBXL8, a novel F-box protein (SCF^F-boxes) of SCF E3 ligase, accelerates BRCA advancement and metastasis. Since SCF^F-boxes is a key component of E3 ligases, we hypothesized that other SCF^F-boxes besides FBXL8 probably collaborate in regulating breast carcinogenesis. In this study, we retrospectively profiled the transcriptome of BRCA tissues and found a notable upregulation of four SCF^F-box E3 ligases (FBXL8, FBXO43, FBXO15, and CCNF) in the carcinoma tissue

SUBMITTER: Chang SC 

PROVIDER: S-EPMC8228695 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature