The Emerging Role of HDACs: Pathology and Therapeutic Targets in Diabetes Mellitus.

ABSTRACT: Diabetes mellitus (DM) is one of the principal manifestations of metabolic syndrome and its prevalence with modern lifestyle is increasing incessantly. Chronic hyperglycemia can induce several vascular complications that were referred to be the major cause of morbidity and mortality in DM. Although several therapeutic targets have been identified and accessed clinically, the imminent risk of DM and its prevalence are still ascending. Substantial pieces of evidence revealed that histone deacetylase (HDAC) isoforms can regulate various molecular activities in DM via epigenetic and post-translational regulation of several transcription factors. To date, 18 HDAC isoforms have been identified in mammals that were categorized into four different classes. Classes I, II, and IV are regarded as cla

SUBMITTER: Dewanjee S 

PROVIDER: S-EPMC8228721 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature