Human Milk Oligosaccharide Profiles over 12 Months of Lactation: The Ulm SPATZ Health Study.

ABSTRACT: Human milk oligosaccharides (HMOs) have specific dose-dependent effects on child health outcomes. The HMO profile differs across mothers and is largely dependent on gene expression of specific transferase enzymes in the lactocytes. This study investigated the trajectories of absolute HMO concentrations at three time points during lactation, using a more accurate, robust, and extensively validated method for HMO quantification. We analyzed human milk sampled at 6 weeks (n = 682), 6 months (n = 448), and 12 months (n = 73) of lactation in a birth cohort study conducted in south Germany, using label-free targeted liquid chromatography mass spectrometry (LC-MS2). We assessed trajectories of HMO concentrations over time and used linear mixed models to explore the effect of secretor status and m

SUBMITTER: Siziba LP 

PROVIDER: S-EPMC8228739 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature