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Target Therapies for NASH/NAFLD: From the Molecular Aspect to the Pharmacological and Surgical Alternatives.


ABSTRACT: Non-alcoholic fatty liver disease represents an increasing cause of chronic hepatic disease in recent years. This condition usually arises in patients with multiple comorbidities, the so-called metabolic syndrome. The therapeutic options are multiple, ranging from lifestyle modifications, pharmacological options, to liver transplantation in selected cases. The choice of the most beneficial one and their interactions can be challenging. It is mandatory to stratify the patients according to the severity of their disease to tailor the available treatments. In our contribution, we review the most recent pharmacological target therapies, the role of bariatric surgery, and the impact of liver transplantation on the NAFLD outcome.

SUBMITTER: Finotti M 

PROVIDER: S-EPMC8229090 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature

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Target Therapies for NASH/NAFLD: From the Molecular Aspect to the Pharmacological and Surgical Alternatives.

Finotti Michele M   Romano Maurizio M   Auricchio Pasquale P   Scopelliti Michele M   Brizzolari Marco M   Grossi Ugo U   Piccino Marco M   Benvenuti Stefano S   Morana Giovanni G   Cillo Umberto U   Zanus Giacomo G  

Journal of personalized medicine 20210602 6


Non-alcoholic fatty liver disease represents an increasing cause of chronic hepatic disease in recent years. This condition usually arises in patients with multiple comorbidities, the so-called metabolic syndrome. The therapeutic options are multiple, ranging from lifestyle modifications, pharmacological options, to liver transplantation in selected cases. The choice of the most beneficial one and their interactions can be challenging. It is mandatory to stratify the patients according to the se  ...[more]

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