Surface Phenotype Changes and Increased Response to Oxidative Stress in CD4⁺CD25^high T Cells.

ABSTRACT: Conversion of CD4⁺CD25⁺FOXP3⁺ T regulatory cells (T_regs) from the immature (CD45RA⁺) to mature (CD45RO⁺) phenotype has been shown during development and allergic reactions. The relative frequencies of these T_reg phenotypes and their responses to oxidative stress during development and allergic inflammation were analysed in samples from paediatric and adult subjects. The FOXP3^lowCD45RA⁺ population was dominant in early childhood, while the percentage of FOXP3^highCD45RO⁺ cells began increasing in the first year of life. These phenotypic changes were observed in subjects with and without asthma. Further, there was a significant increase in phosphorylated ERK1/2 (pERK1/2) pr

SUBMITTER: Yamamoto Y 

PROVIDER: S-EPMC8229188 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature