A synbiotic intervention modulates meta-omics signatures of gut redox potential and acidity in elective caesarean born infants.

ABSTRACT:

Background

The compromised gut microbiome that results from C-section birth has been hypothesized as a risk factor for the development of non-communicable diseases (NCD). In a double-blind randomized controlled study, 153 infants born by elective C-section received an infant formula supplemented with either synbiotic, prebiotics, or unsupplemented from birth until 4 months old. Vaginally born infants were included as a reference group. Stool samples were collected from day 3 till week 22. Multi-omics were deployed to investigate the impact of mode of delivery and nutrition on the development of the infant gut microbiome, and uncover putative biological mechanisms underlying the role of a compromised microbiome as a risk factor for NCD.

Results

As early as day 3, infants born

SUBMITTER: Lay C 

PROVIDER: S-EPMC8229302 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature