Ultrasound-Triggered Release of 5-Fluorouracil from Soy Lecithin Echogenic Liposomes.

ABSTRACT: Colorectal cancer is the third most diagnosed cancer and the second leading cause of death. The use of 5-fluorouracil (5-FU) has been the major chemotherapeutic treatment for colorectal cancer patients. However, the efficacy of 5-FU is limited by drug resistance, and bone marrow toxicity through high-level expression of thymidylate synthase, justifying the need for improvement of the therapeutic index. In this study, the effects of ultrasound on echogenic 5-FU encapsulated crude soy liposomes were investigated for their potential to address these challenges. Liposomes were prepared by thin-film hydration using crude soy lecithin and cholesterol. Argon gas was entrapped in the liposomes for sonosensitivity (that is, responsiveness to ultrasound). The nanoparticles were characterized for par

SUBMITTER: Ezekiel CI 

PROVIDER: S-EPMC8229429 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature